 | Droncit Spot On
Whilst your Droncit purchase may have saved you money, you have missed that valuable contact with your Vet which gives you the opportunity to ensure that you are using it correctly. In order to make up for this we urge you to take the time to read through the Data Sheet below paying particular attention to the Contra Indications and Warnings. If you are left with any questions or concerns please email info@petvetcare.co.uk. Please remember that Droncit is not for resale.
(instructions will be included in the Droncit packaging)
Presentation
A clear, colourless to slightly reddish, non-aqueous solution containing 20 mg praziquantel Ph Eur per 0.5 ml tube, for spot-on (cutaneous) application for cats.
Uses
For the treatment of tapeworms of cats. Droncit Spot-On is effective against mature and immature forms of Dipylidium caninum and Taenia species. The product is also effective against Echinococcus multilocularis
Dosage and administration
The minimum dose rate is 8 mg/kg which equates to 1 tube per 2.5 kg bodyweight.
Bodyweight 1-2.5kg Equals - 1 tube
Bodyweight 2.5-5kg Equals - 2 tubes
Bodyweight 5kg Equals - 3 tubes
Administration
Remove one tube from the package. Hold tube in an upright position, twist and pull off cap. Use reversed cap to twist and remove seal from tube.
Open a tube
Part the hair on the cat's neck at the base of the skull until the skin is visible.
Place the tip of the tube on the skin and squeeze firmly several times to empty the contents directly onto the skin. Application at the base of the skull will minimise the opportunity for the cat to lick the product.
To minimise the possibility of run-off after application of more than one pipette, it is advised that the applications should be performed slowly to allow absorption and that it may be advisable to allow the contents of the previous tube to be absorbed before applying another.
Tapeworm infection is certain to re-occur unless control of the intermediate hosts such as fleas, mice, etc, is undertaken.
Flea control
Flea infestations can be controlled by the regular use of effective flea control remedies.
Mice control
If cats roam and hunt, contact with, and consumption of, mice and subsequent re-infestation with Taenia taeniaeformis is impossible to prevent.
It is recommended to re-apply Droncit Spot-On when signs of tapeworm infection re-appear or at monthly intervals.
Use During Pregnancy and Lactation
There are no contra-indications against use during pregnancy and lactation.
Contra-indications, warnings, etc
For external use only.
Do not use on cats weighing less than 1 kg bodyweight.
Occasionally a transient local reaction such as scurf or mild exudation may be observed at the application site following treatment.
The product is bitter tasting and salivation may occasionally occur if the cat licks the application site immediately after treatment. This is not a sign of intoxication and disappears after a short time without treatment.
Overdosing can lead to slight skin reactions which disappear without treatment within a few days.
Care should be taken to avoid the contents of the tube coming into contact with the eyes or mouth of the recipient animal.
Do not allow recently treated animals to groom each other.
Operator safety
This product can be irritant to the skin and eyes.
Care should be taken to prevent contact of the solution with the skin or eyes.
If contact with the skin occurs, wash off any skin contamination with soap and water immediately.
If accidental contact occurs with the eyes, flush the affected eyes thoroughly with clean fresh water.
In the event of skin or eye contact, seek medical advice if irritation persists and show the Doctor this package.
Do not stroke or groom animals until area of application is dry (typically around 1 hour after application).
Wash hands thoroughly after use.
Do not eat, drink or smoke during application.
Environmental safety
Any unused product or waste material should be disposed of in accordance with national requirements.
Pharmaceutical precautions
Store away from food, drink and animal feeding stuffs.
Do not use after expiry date.
Legal category
AVM-GSL (previously GSL)
Further information
Praziquantel, the active ingredient of Droncit® Spot-on is a pyrazinoisoquinoline derivative used widely as an anthelmintic for both human and veterinary medicine.
Praziquantel is effective against all stages of development of intestinal tapeworms. The substance is very rapidly absorbed and distributed throughout the parasite. Both in vivo and in vitro studies have shown that praziquantel causes severe damage to the parasite integument, resulting in contraction and paralysis. There is an almost instantaneous tetanic contraction of the parasite musculature and a rapid vacuolisation of the syncytial tegument. This rapid contraction has been explained by changes in divalent cation fluxes, particularly calcium.
Praziquantel is absorbed very rapidly and almost completely in the stomach and small intestine. Studies of the behaviour following oral administration have been conduced in rats, dogs, monkeys, sheep and humans. Depending on species, maximum serum levels are reached within 0.3 to 2 hours. The chemical is evenly distributed to all organs. The elimination half-lives of 14C-praziquantel and its metabolites are between 2 and 3 hours in rats, dogs, monkeys and sheep.
Praziquantel is rapidly metabolised in the liver in both humans and animals with the 4-hydroxycyclohexyl derivative as the main metabolite. Praziquantel is completely eliminated from the body within 48 hours; irreversible binding to body constituents has not been observed. Elimination is in the form of metabolites with virtually no parent compound excreted. Between 40% and 71% of the substance is eliminated in the urine and 13%-30% in the faeces.
No incompatibility has been observed between this product at the recommended dose and a range of common veterinary treatments.
Marketing authorisation number
Vm 00010/4105.
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